Rab7 Silencing Prevents μ-Opioid Receptor Lysosomal Targeting and Rescues Opioid Responsiveness to Strengthen Diabetic Neuropathic Pain Therapy

Painful diabetic neuropathy is poorly controlled by analgesics and requires high doses of opioids, triggering side effects and reducing patient quality of life. This study investigated whether enhanced Rab7-mediated lysosomal targeting of peripheral sensory neuron μ-opioid receptors (MORs) is respon...

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Bibliographic Details
Main Authors: Mousa, Shaaban A., Shaqura, Mohammed, Khalefa, Baled I., Zöllner, Christian, Schaad, Laura, Schneider, Jonas, Shippenberg, Toni S., Richter, Jan F., Hellweg, Rainer, Shakibaei, Mehdi, Schäfer, Michael
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2013
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609597/
https://ncbi.nlm.nih.gov/pubmed/23230081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0590
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