Possible involvement of prolonging spinal μ-opioid receptor desensitization in the development of antihyperalgesic tolerance to μ-opioids under a neuropathic pain-like state

In the present study, we investigated the possible development of tolerance to the antihyperalgesic effect of μ-opioid receptor (MOR) agonists under a neuropathic pain-like state. Repeated treatment with fentanyl, but not morphine or oxycodone, produced a rapid development of tolerance to its antihy...

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Autors principals: Narita, Minoru, Imai, Satoshi, Nakamura, Atsushi, Ozeki, Ayumi, Asato, Megumi, Rahmadi, Mahardian, Sudo, Yuka, Hojo, Minoru, Uezono, Yasuhito, Devi, Lakshmi A., Kuzumaki, Naoko, Suzuki, Tsutomu
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852690/
https://ncbi.nlm.nih.gov/pubmed/21812868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1369-1600.2011.00354.x
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