Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain

Although opioids are highly effective analgesics, they are also known to induce cellular adaptations resulting in tolerance. Experimental studies are often performed in the absence of painful tissue injury, which precludes extrapolation to the clinical situation. Here we show that rats with chronic...

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Autores principales: Zöllner, Christian, Mousa, Shaaban A., Fischer, Oliver, Rittner, Heike L., Shaqura, Mohammed, Brack, Alexander, Shakibaei, Mehdi, Binder, Waltraud, Urban, Florian, Stein, Christoph, Schäfer, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214843/
https://ncbi.nlm.nih.gov/pubmed/18246198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25911
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