Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression

The molecular mechanisms regulating leukemia-initiating cell (LIC) function are of important clinical significance. We use chronic myelogenous leukemia (CML), as a model of LIC-dependent malignancy and identify the interaction between the ubiquitin ligase Fbw7 and its substrate c-Myc as a regulator...

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Détails bibliographiques
Auteurs principaux: Reavie, Linsey, Buckley, Shannon M., Loizou, Evangelia, Takeishi, Shoichiro, Aranda-Orgilles, Beatriz, Ndiaye-Lobry, Delphine, Abdel-Wahab, Omar, Ibrahim, Sherif, Nakayama, Keiichi I., Aifantis, Iannis
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609428/
https://ncbi.nlm.nih.gov/pubmed/23518350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.01.025
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