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Small molecule inhibitors of RORγt: Targeting Th17 cells and other applications

Nuclear hormone receptors (NHRs) form a family of transcription factors that are composed of modular protein structures with DNA- and ligand-binding domains (DBDs and LBDs). The DBDs confer gene target site specificity, whereas LBDs serve as control switches for NHR function. For many NHRs, both end...

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Hlavní autoři: Huh, Jun R., Littman, Dan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609417/
https://ncbi.nlm.nih.gov/pubmed/22949321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242740
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