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Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A(2) and synapse damage

Precisely how the accumulation of PrP(Sc) causes the neuronal degeneration that leads to the clinical symptoms of prion diseases is poorly understood. Our recent paper showed that the clustering of specific glycosylphosphatidylinositol (GPI) anchors attached to PrP proteins triggered synapse damage...

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Bibliografiske detaljer
Main Authors: Bate, Clive, Williams, Alun
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609062/
https://ncbi.nlm.nih.gov/pubmed/22895089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.21751
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