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Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A(2) and synapse damage
Precisely how the accumulation of PrP(Sc) causes the neuronal degeneration that leads to the clinical symptoms of prion diseases is poorly understood. Our recent paper showed that the clustering of specific glycosylphosphatidylinositol (GPI) anchors attached to PrP proteins triggered synapse damage...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3609062/ https://ncbi.nlm.nih.gov/pubmed/22895089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.21751 |
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