PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy

Oncogenic PI3K/mTOR activation is frequently observed in human cancers and activates cell motility via p27 phosphorylations at T157 and T198. Here we explored the potential for a novel PI3K/mTOR inhibitor to inhibit tumor invasion and metastasis. An MDA-MB-231 breast cancer line variant, MDA-MB-231-...

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Detalhes bibliográficos
Main Authors: Wander, Seth A., Zhao, Dekuang, Besser, Alexandra H., Hong, Feng, Wei, Jianqin, Ince, Tan A., Milikowski, Clara, Bishopric, Nanette H., Minn, Andy J., Creighton, Chad J., Slingerland, Joyce M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
Assuntos:
Preclinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608882/
https://ncbi.nlm.nih.gov/pubmed/23430223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-012-2389-6
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