A Critical Role for Toll-like Receptor-4 Induction of Autophagy in the Regulation of Enterocyte Migration and the Pathogenesis of Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) develops in response to elevated Toll-like receptor-4 (TLR4) signaling in the newborn intestinal epithelium, and is characterized by TLR4-mediated inhibition of enterocyte migration and reduced mucosal healing. The downstream processes by which TLR4 impairs mucosal he...

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Hauptverfasser: Neal, Matthew D., Sodhi, Chhinder P., Dyer, Mitchell, Craig, Brian T., Good, Misty, Jia, Hongpeng, Yazji, Ibrahim, Afrazi, Amin, Richardson, Ward M., Beer-Stolz, Donna, Prindle, Thomas, Grant, Zachary, Branca, Maria F., Ozolek, John, Hackam, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608826/
https://ncbi.nlm.nih.gov/pubmed/23455503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202264
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