Leptin-induced RORγt expression in CD4(+) T cells promotes Th17 responses in systemic lupus erythematosus()

Th17 CD4(+) cells promote inflammation and autoimmunity. Here we report that Th17 cell frequency is reduced in ob/ob mice that are genetically deficient in the adipokine leptin, and that the administration of leptin to ob/ob mice restored Th17 cell numbers to values comparable to those found in wild...

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Bibliographic Details
Main Authors: Yu, Yiyun, Liu, Yaoyang, Shi, Fu-Dong, Zou, Hejian, Matarese, Giuseppe, Cava, Antonio La
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608794/
https://ncbi.nlm.nih.gov/pubmed/23447682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203275
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