1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of Toll-Like Receptor Signaling via Targeting MicroRNA-155-SOCS1 in Macrophages

The negative feedback mechanism is essential to maintain effective immunity and tissue homeostasis. 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) modulates innate immune response, but the mechanism remains poorly understood. Here we report that vitamin D receptor (VDR) signaling attenuates Toll-like rec...

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Detalhes bibliográficos
Main Authors: Chen, Yunzi, Liu, Weicheng, Sun, Tao, Huang, Yong, Wang, Youli, Deb, Dilip K., Yoon, Dosuk, Kong, Juan, Thadhani, Ravi, Li, Yan Chun
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608760/
https://ncbi.nlm.nih.gov/pubmed/23436936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203273
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