1,25-Dihydroxyvitamin D(3) suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-κB pathway

The renin-angiotensin system (RAS) is a major mediator of renal injury in diabetic nephropathy. Our previous studies demonstrated that 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] plays a renoprotective role by suppressing the RAS, with renin and angiotensinogen (AGT) as the main targets. The mechan...

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Detalhes bibliográficos
Main Authors: Deb, Dilip K., Chen, Yunzi, Zhang, Zhongyi, Zhang, Yan, Szeto, Frances L., Wong, Kari E., Kong, Juan, Li, Yan Chun
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681355/
https://ncbi.nlm.nih.gov/pubmed/19193728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00002.2009
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