A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells

The molecular mechanism of the extrathymic generation of adaptive CD4(+)Foxp3(+) regulatory T (iTreg) cells remains incompletely defined. We show that exposure of splenic CD4(+)CD25(+)Foxp3(−) cells to IL-2, but not other γc cytokines, resulted in Stat5 phosphorylation and induced Foxp3 expression i...

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Bibliographische Detailangaben
Hauptverfasser: Guo, Zhiyong, Khattar, Mithun, Schroder, Paul M., Miyahara, Yoshihiro, Wang, Guohua, He, Xiaoshung, Chen, Wenhao, Stepkowski, Stanislaw M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608742/
https://ncbi.nlm.nih.gov/pubmed/23427250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200751
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