Interleukin-21 Is a Critical Regulator of CD4 and CD8 T Cell Survival during Priming under Interleukin-2 Deprivation Conditions

Optimal T cell activation and expansion require binding of the common gamma-chain (γc) cytokine Interleukin-2 (IL-2) to its cognate receptor that in turn engages a γc/Janus tyrosine kinase (Jak)3 signaling pathway. Because of its restricted expression by antigen-activated T cells and its obligatory...

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Detaylı Bibliyografya
Asıl Yazarlar: Khattar, Mithun, Miyahara, Yoshihiro, Schroder, Paul M., Xie, Aini, Chen, Wenhao, Stepkowski, Stanislaw M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887105/
https://ncbi.nlm.nih.gov/pubmed/24416451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085882
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