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A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells
The molecular mechanism of the extrathymic generation of adaptive CD4(+)Foxp3(+) regulatory T (iTreg) cells remains incompletely defined. We show that exposure of splenic CD4(+)CD25(+)Foxp3(−) cells to IL-2, but not other γc cytokines, resulted in Stat5 phosphorylation and induced Foxp3 expression i...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608742/ https://ncbi.nlm.nih.gov/pubmed/23427250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200751 |
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