β2 adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/Protein Kinase A-independent pathway

Activation of the β2 adrenergic receptor (β2AR) on immune cells has been reported to possess anti-inflammatory properties, however, the pro-inflammatory properties of β2AR activation remain unclear. In this study, using rat primary mesencephalic neuron-glia cultures, we report that salmeterol, a lon...

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Hauptverfasser: Qian, Li, Hu, Xiaoming, Zhang, Dan, Snyder, Amanda, Wu, Hung-ming, Li, Yachen, Wilson, Belinda, Lu, Ru-Bin, Hong, Jau-Shyong, Flood, Patrick M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608678/
https://ncbi.nlm.nih.gov/pubmed/19330844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20873
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