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Reversion of Somatic Mutations of the Respiratory Syncytial Virus-Specific Human Monoclonal Antibody Fab19 Reveal a Direct Relationship Between Association Rate and Neutralizing Potency
The role of affinity in determining neutralizing potency of monoclonal antibodies directed against viruses is not well understood. We investigated the kinetic, structural, and functional advantage conferred by individual naturally-occurring somatic mutations in the antibody heavy chain variable regi...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608519/ https://ncbi.nlm.nih.gov/pubmed/23455501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202964 |
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