Lactose binding to human galectin-7 (p53-induced gene 1) induces long-range effects through the protein resulting in increased dimer stability and evidence for positive cooperativity

The product of p53-induced gene 1 is a member of the galectin family, i.e., galectin-7 (Gal-7). To move beyond structural data by X-ray diffraction, we initiated the study of the lectin by nuclear magnetic resonance (NMR) and circular dichroism spectroscopies, and molecular dynamics (MD) simulations...

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Autori principali: Ermakova, Elena, Miller, Michelle C, Nesmelova, Irina V, López-Merino, Lara, Berbís, Manuel Alvaro, Nesmelov, Yuri, Tkachev, Yaroslav V, Lagartera, Laura, Daragan, Vladimir A, André, Sabine, Cañada, F Javier, Jiménez-Barbero, Jesús, Solís, Dolores, Gabius, Hans-Joachim, Mayo, Kevin H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608354/
https://ncbi.nlm.nih.gov/pubmed/23376190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwt005
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