Remodeling of the cardiac sodium channel, Connexin43 and Plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy

BACKGROUND: Arrhythmogenic cardiomyopathy (AC) is tightly associated with desmosomal mutations in the majority of patients. Arrhythmogenesis in AC patients is likely related to remodeling of cardiac gap junctions and increased levels of fibrosis. Recently, using experimental models, we also identifi...

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Autori principali: Noorman, Maartje, Hakim, Sara, Kessler, Elise, Groeneweg, Judith, Cox, Moniek GPJ, Asimaki, Angeliki, van Rijen, Harold VM, van Stuijvenberg, Leonie, Chkourko, Halina, van der Heyden, Marcel AG, Vos, Marc A, de Jonge, Nicolaas, van der Smagt, Jasper J, Dooijes, Dennis, Vink, Aryan, de Weger, Roel A, Varro, Andras, de Bakker, Jacques MT, Saffitz, Jeffrey E, Hund, Thomas J, Mohler, Peter J, Delmar, Mario, Hauer, Richard NW, van Veen, Toon AB
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608196/
https://ncbi.nlm.nih.gov/pubmed/23178689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2012.11.018
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