Reduced Heterogeneous Expression Of Cx43 Results In Decreased Nav1.5 Expression And Reduced Sodium Current Which Accounts For Arrhythmia Vulnerability In Conditional Cx43 Knockout Mice

BACKGROUND: Reduced Connexin43 (Cx43), sodium channel (Nav1.5) expression and increased collagen expression (fibrosis) are important determinants of impulse conduction in the heart. OBJECTIVE: To study the importance and interaction of these factors at very low Cx43 expression, inducible Cx43 KO mic...

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Главные авторы: Jansen, John A., Noorman, Maartje, Musa, Hassan, Stein, Mèra, de Jong, Sanne, van der Nagel, Roel, Hund, Thomas J., Mohler, Peter J., Vos, Marc A., van Veen, Toon A., de Bakker, Jacques M., Delmar, Mario, van Rijen, Harold V.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336370/
https://ncbi.nlm.nih.gov/pubmed/22100711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2011.11.025
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