Reduced Heterogeneous Expression Of Cx43 Results In Decreased Nav1.5 Expression And Reduced Sodium Current Which Accounts For Arrhythmia Vulnerability In Conditional Cx43 Knockout Mice

BACKGROUND: Reduced Connexin43 (Cx43), sodium channel (Nav1.5) expression and increased collagen expression (fibrosis) are important determinants of impulse conduction in the heart. OBJECTIVE: To study the importance and interaction of these factors at very low Cx43 expression, inducible Cx43 KO mic...

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Main Authors: Jansen, John A., Noorman, Maartje, Musa, Hassan, Stein, Mèra, de Jong, Sanne, van der Nagel, Roel, Hund, Thomas J., Mohler, Peter J., Vos, Marc A., van Veen, Toon A., de Bakker, Jacques M., Delmar, Mario, van Rijen, Harold V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336370/
https://ncbi.nlm.nih.gov/pubmed/22100711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2011.11.025
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