Remodeling of the cardiac sodium channel, Connexin43 and Plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy

BACKGROUND: Arrhythmogenic cardiomyopathy (AC) is tightly associated with desmosomal mutations in the majority of patients. Arrhythmogenesis in AC patients is likely related to remodeling of cardiac gap junctions and increased levels of fibrosis. Recently, using experimental models, we also identifi...

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Main Authors: Noorman, Maartje, Hakim, Sara, Kessler, Elise, Groeneweg, Judith, Cox, Moniek GPJ, Asimaki, Angeliki, van Rijen, Harold VM, van Stuijvenberg, Leonie, Chkourko, Halina, van der Heyden, Marcel AG, Vos, Marc A, de Jonge, Nicolaas, van der Smagt, Jasper J, Dooijes, Dennis, Vink, Aryan, de Weger, Roel A, Varro, Andras, de Bakker, Jacques MT, Saffitz, Jeffrey E, Hund, Thomas J, Mohler, Peter J, Delmar, Mario, Hauer, Richard NW, van Veen, Toon AB
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608196/
https://ncbi.nlm.nih.gov/pubmed/23178689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2012.11.018
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