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Activation of cAMP-Protein kinase A abrogates STAT5-mediated inhibition of glucocorticoid receptor signaling by interferon-alpha
IFN-alpha has been found to inhibit glucocorticoid receptor (GR) function by activating janus kinase-signal transducer and activator of transcription (JAK-STAT) inflammatory signaling pathways. In contrast, through stimulation of protein kinase A (PKA), cAMP has been shown to enhance GR function and...
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| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608107/ https://ncbi.nlm.nih.gov/pubmed/21798341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2011.07.227 |
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