A permissive chromatin structure is adopted prior to site-specific DNA demethylation of developmentally expressed genes involved in macronuclear differentiation

BACKGROUND: DNA methylation and demethylation are important epigenetic regulatory mechanisms in eukaryotic cells and, so far, only partially understood. We exploit the minimalistic biological ciliate system to understand the crosstalk between DNA modification and chromatin structure. In the macronuc...

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Main Authors: Bulic, Aneta, Postberg, Jan, Fischer, Andreas, Jönsson, Franziska, Reuter, Günter, Lipps, Hans J
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608066/
https://ncbi.nlm.nih.gov/pubmed/23497475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-6-5
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