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An Improved Synthesis of BrettPhos and RockPhos-Type Biarylphosphine Ligands

Improved processes for the preparation of biphenyl-based phosphine ligands t-BuBrettPhos, RockPhos, and BrettPhos are presented. The new methods, featuring the use of Grignard reagents and catalytic amounts of copper, are superior to the previous methods, which require the use of t-butyllithium and...

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Autors principals: Hoshiya, Naoyuki, Buchwald, Stephen L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607394/
https://ncbi.nlm.nih.gov/pubmed/23539491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.201200398
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