Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer

Intratumoral synthesis of dihydrotestosterone (DHT) from precursors cannot completely explain the castration resistance of prostate cancer. We showed that DHT was intratumorally synthesized from the inactive androgen metabolites 5α-androstane-3α/β,17β-diol (3α/β-diol) in prostate cancer cells via di...

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Main Authors: Ishizaki, Fumio, Nishiyama, Tsutomu, Kawasaki, Takashi, Miyashiro, Yoshimichi, Hara, Noboru, Takizawa, Itsuhiro, Naito, Makoto, Takahashi, Kota
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607121/
https://ncbi.nlm.nih.gov/pubmed/23524847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01528
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