Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β,17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone

Intratumoural dihydrotestosterone (DHT) synthesis could be an explanation for castration resistance in prostate cancer (PC). By using liquid chromatography-mass spectrometry, we evaluated the intratumoral DHT synthesis from 5α-androstane-3β,17β-diol (3β-diol), which is inactive androgen metabolized...

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Publicado no:Sci Rep
Main Authors: Ando, Takashi, Nishiyama, Tsutomu, Takizawa, Itsuhiro, Ishizaki, Fumio, Miyashiro, Yoshimichi, Takeda, Keisuke, Hara, Noboru, Tomita, Yoshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999866/
https://ncbi.nlm.nih.gov/pubmed/27561382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32198
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