Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer

Intratumoral synthesis of dihydrotestosterone (DHT) from precursors cannot completely explain the castration resistance of prostate cancer. We showed that DHT was intratumorally synthesized from the inactive androgen metabolites 5α-androstane-3α/β,17β-diol (3α/β-diol) in prostate cancer cells via di...

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Detalhes bibliográficos
Main Authors: Ishizaki, Fumio, Nishiyama, Tsutomu, Kawasaki, Takashi, Miyashiro, Yoshimichi, Hara, Noboru, Takizawa, Itsuhiro, Naito, Makoto, Takahashi, Kota
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607121/
https://ncbi.nlm.nih.gov/pubmed/23524847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01528
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