Ordering a Dynamic Protein Via a Small Molecule Stabilizer

Like many coactivators, the GACKIX domain of the master coactivator CBP/p300 recognizes transcriptional activators of diverse sequence composition via dynamic binding surfaces. The conformational dynamics of GACKIX that underlie its function also render it especially challenging for structural chara...

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Detalhes bibliográficos
Main Authors: Wang, Ningkun, Majmudar, Chinmay Y., Pomerantz, William C., Gagnon, Jessica K., Sadowsky, Jack D., Meagher, Jennifer L., Johnson, Taylor K., Stuckey, Jeanne A., Brooks, Charles L., Wells, James A., Mapp, Anna K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607081/
https://ncbi.nlm.nih.gov/pubmed/23384013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3122334
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