MECHANISMS OF EMPHYSEMA IN AUTOSOMAL DOMINANT CUTIS LAXA

Heterozygous elastin gene mutations cause autosomal dominant cutis laxa associated with emphysema and aortic aneurysms. To investigate the molecular mechanisms leading to cutis laxa in vivo, we generated transgenic mice by pronuclear injection of minigenes encoding normal human tropoelastin (WT) or...

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Detalhes bibliográficos
Main Authors: Hu, Qirui, Shifren, Adrian, Sens, Carla, Choi, Jiwon, Szabo, Zoltan, Starcher, Barry C., Knutsen, Russell H., Shipley, J. Michael, Davis, Elaine C., Mecham, Robert P., Urban, Zsolt
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606561/
https://ncbi.nlm.nih.gov/pubmed/20600892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2010.06.005
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