MECHANISMS OF EMPHYSEMA IN AUTOSOMAL DOMINANT CUTIS LAXA

Heterozygous elastin gene mutations cause autosomal dominant cutis laxa associated with emphysema and aortic aneurysms. To investigate the molecular mechanisms leading to cutis laxa in vivo, we generated transgenic mice by pronuclear injection of minigenes encoding normal human tropoelastin (WT) or...

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Bibliografiske detaljer
Main Authors: Hu, Qirui, Shifren, Adrian, Sens, Carla, Choi, Jiwon, Szabo, Zoltan, Starcher, Barry C., Knutsen, Russell H., Shipley, J. Michael, Davis, Elaine C., Mecham, Robert P., Urban, Zsolt
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606561/
https://ncbi.nlm.nih.gov/pubmed/20600892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2010.06.005
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