11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

11β-Hydroxysteroid dehydrogenase type-1 (11β-HSD1) converts inert cortisone into active cortisol, amplifying intracellular glucocorticoid action. 11β-HSD1 deficiency improves cardiovascular risk factors in obesity but exacerbates acute inflammation. To determine the effects of 11β-HSD1 deficiency on...

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Autori principali: Kipari, Tiina, Hadoke, Patrick W. F., Iqbal, Javaid, Man, Tak-Yung, Miller, Eileen, Coutinho, Agnes E., Zhang, Zhenguang, Sullivan, Katie M., Mitic, Tijana, Livingstone, Dawn E. W., Schrecker, Christopher, Samuel, Kay, White, Christopher I., Bouhlel, M. Amine, Chinetti-Gbaguidi, Giulia, Staels, Bart, Andrew, Ruth, Walker, Brian R., Savill, John S., Chapman, Karen E., Seckl, Jonathan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2013
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606528/
https://ncbi.nlm.nih.gov/pubmed/23303209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-219105
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