Peroxisome proliferator-activated receptor ɣ activation induces 11β-hydroxysteroid dehydrogenase type 1 activity in human alternative macrophages

OBJECTIVES: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyses the intracellular reduction of inactive cortisone to active cortisol, the natural ligand activating the glucocorticoid receptor (GR). Peroxisome Proliferator-Activated Receptor gamma (PPARγ) is a nuclear receptor controlling in...

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Hauptverfasser: Chinetti-Gbaguidi, Giulia, Bouhlel, Mohamed Amine, Copin, Corinne, Duhem, Christian, Derudas, Bruno, Neve, Bernardette, Noel, Benoit, Eeckhoute, Jerome, Lefebvre, Philippe, Seckl, Jonathan R., Staels, Bart
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lippincott Williams & Wilkins 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428270/
https://ncbi.nlm.nih.gov/pubmed/22207732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.241364
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