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A Comparison of the Molecular Bases for N-Methyl-d-Aspartate-Receptor Inhibition Versus Immobilizing Activities of Volatile Aromatic Anesthetics

BACKGROUND: Aromatic anesthetics exhibit a wide range of N-methyl-d-aspartate (NMDA) receptor inhibitory potencies and immobilizing activities. We sought to characterize the molecular basis of NMDA receptor inhibition using comparative molecular field analysis (CoMFA), and compare the results to tho...

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Detalhes bibliográficos
Main Authors: Sewell, Jason C., Raines, Douglas E., Eger, Edmond I, Laster, Michael J., Sear, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606081/
https://ncbi.nlm.nih.gov/pubmed/19095845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ane.0b013e31818de158
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