A novel approach to oral apoA-I mimetic therapy

Transgenic tomato plants were constructed with an empty vector (EV) or a vector expressing an apoA-I mimetic peptide, 6F. EV or 6F tomatoes were harvested, lyophilized, ground into powder, added to Western diet (WD) at 2.2% by weight, and fed to LDL receptor-null (LDLR(−/−)) mice at 45 mg/kg/day 6F....

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Main Authors: Chattopadhyay, Arnab, Navab, Mohamad, Hough, Greg, Gao, Feng, Meriwether, David, Grijalva, Victor, Springstead, James R., Palgnachari, Mayakonda N., Namiri-Kalantari, Ryan, Su, Feng, Van Lenten, Brian J., Wagner, Alan C., Anantharamaiah, G. M., Farias-Eisner, Robin, Reddy, Srinivasa T., Fogelman, Alan M.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606004/
https://ncbi.nlm.nih.gov/pubmed/23378594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M033555
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