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Cellular Polyamines Promote Amyloid-Beta (Aβ) Peptide Fibrillation and Modulate the Aggregation Pathways

[Image: see text] The cellular polyamines spermine, spermidine, and their metabolic precursor putrescine, have long been associated with cell-growth, tumor-related gene regulations, and Alzheimer’s disease. Here, we show by in vitro spectroscopy and AFM imaging, that these molecules promote aggregat...

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Main Authors: Luo, Jinghui, Yu, Chien-Hung, Yu, Huixin, Borstnar, Rok, Kamerlin, Shina C. L., Gräslund, Astrid, Abrahams, Jan Pieter, Wärmländer, Sebastian K. T. S.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2013
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605822/
https://ncbi.nlm.nih.gov/pubmed/23509981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300170x
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