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Central Synapses Release a Resource-Efficient Amount of Glutamate

Why synapses release a certain amount of neurotransmitter is poorly understood. Here we combine patch-clamp electrophysiology with computer simulations to estimate how much glutamate is discharged at two distinct central synapses of the rat. We find that, regardless of some uncertainty over synaptic...

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Detalles Bibliográficos
Main Authors: Savtchenko, Leonid P., Sylantyev, Sergiy, Rusakov, Dmitri A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605778/
https://ncbi.nlm.nih.gov/pubmed/23242311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3285
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