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Spike-Driven Glutamate Electrodiffusion Triggers Synaptic Potentiation via a Homer-Dependent mGluR-NMDAR Link

Electric fields of synaptic currents can influence diffusion of charged neurotransmitters, such as glutamate, in the synaptic cleft. However, this phenomenon has hitherto been detected only through sustained depolarization of large principal neurons, and its adaptive significance remains unknown. He...

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Hlavní autoři: Sylantyev, Sergiy, Savtchenko, Leonid P., Ermolyuk, Yaroslav, Michaluk, Piotr, Rusakov, Dmitri A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568920/
https://ncbi.nlm.nih.gov/pubmed/23395378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.11.026
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