Drug Uptake, Lipid Rafts, and Vesicle Trafficking Modulate Resistance to an Anticancer Lysophosphatidylcholine Analogue in Yeast

The ether-phospholipid edelfosine, a prototype antitumor lipid (ATL), kills yeast cells and selectively kills several cancer cell types. To gain insight into its mechanism of action, we performed chemogenomic screens in the Saccharomyces cerevisiae gene-deletion strain collection, identifying edelfo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cuesta-Marbán, Álvaro, Botet, Javier, Czyz, Ola, Cacharro, Luis M., Gajate, Consuelo, Hornillos, Valentín, Delgado, Javier, Zhang, Hui, Amat-Guerri, Francisco, Acuña, A. Ulises, McMaster, Christopher R., Revuelta, José Luis, Zaremberg, Vanina, Mollinedo, Faustino
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Lipids
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605657/
https://ncbi.nlm.nih.gov/pubmed/23335509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425769
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