Intracellular Triggering of Fas Aggregation and Recruitment of Apoptotic Molecules into Fas-enriched Rafts in Selective Tumor Cell Apoptosis

We have discovered a new and specific cell-killing mechanism mediated by the selective uptake of the antitumor drug 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH(3), Edelfosine) into lipid rafts of tumor cells, followed by its coaggregation with Fas death receptor (also known as A...

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Detalhes bibliográficos
Main Authors: Gajate, Consuelo, del Canto-Jañez, Esther, Acuña, A. Ulises, Amat-Guerri, Francisco, Geijo, Emilio, Santos-Beneit, Antonio M., Veldman, Robert J., Mollinedo, Faustino
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211978/
https://ncbi.nlm.nih.gov/pubmed/15289504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040213
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