Drug Uptake, Lipid Rafts, and Vesicle Trafficking Modulate Resistance to an Anticancer Lysophosphatidylcholine Analogue in Yeast

The ether-phospholipid edelfosine, a prototype antitumor lipid (ATL), kills yeast cells and selectively kills several cancer cell types. To gain insight into its mechanism of action, we performed chemogenomic screens in the Saccharomyces cerevisiae gene-deletion strain collection, identifying edelfo...

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Autores principales: Cuesta-Marbán, Álvaro, Botet, Javier, Czyz, Ola, Cacharro, Luis M., Gajate, Consuelo, Hornillos, Valentín, Delgado, Javier, Zhang, Hui, Amat-Guerri, Francisco, Acuña, A. Ulises, McMaster, Christopher R., Revuelta, José Luis, Zaremberg, Vanina, Mollinedo, Faustino
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605657/
https://ncbi.nlm.nih.gov/pubmed/23335509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425769
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