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Cell type-specific responses of human cells to inhibition of replication licensing

Replication origins are “licensed” for a single initiation event by loading Mcm2-7 complexes during late mitosis and G1. Licensing is blocked at other cell cycle stages by the activity of cyclin-dependent kinases and a small protein called geminin. Here, we describe the effects of over-expressing a...

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Bibliografiset tiedot
Päätekijät: Shreeram, S., Sparks, Alison, Lane, David P., Blow, J. Julian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2002
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605503/
https://ncbi.nlm.nih.gov/pubmed/12242660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1205910
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