The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant

5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials. Despite its multiple biological functions, DMXAA has not been fully characterized...

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Autori principali: Tang, Choon Kit, Aoshi, Taiki, Jounai, Nao, Ito, Junichi, Ohata, Keiichi, Kobiyama, Kouji, Dessailly, Benoit H., Kuroda, Etsushi, Akira, Shizuo, Mizuguchi, Kenji, Coban, Cevayir, Ishii, Ken J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605442/
https://ncbi.nlm.nih.gov/pubmed/23555875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060038
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