PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production

Studies examining the role of PD-L2/PD-1 in asthma have yielded conflicting results. To clarify its role, we examined PD-L2 expression in biopsies from human asthmatics and lungs of aeroallergen-treated mice. PD-L2 expression in bronchial biopsies correlated with the severity of asthma. In mice, all...

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Détails bibliographiques
Auteurs principaux: Lewkowich, IP, Lajoie, S, Stoffers, SL, Suzuki, Y, Richgels, PK, Dienger, K, Sproles, AA, Yagita, H, Hamid, Q, Wills-Karp, M
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605233/
https://ncbi.nlm.nih.gov/pubmed/23149662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.111
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