The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.

We have established the human nck sequence as a new oncogene. Nck encodes one SH2 and three SH3 domains, the Src homology motifs found in nonreceptor tyrosine kinases, Ras GTPase-activating protein, phosphatidylinositol 3-kinase, and phospholipase C-gamma. Overexpression of human nck in 3Y1 rat fibr...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Chou, M M, Fajardo, J E, Hanafusa, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360523/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1280326/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.12.5834-5842.1992
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