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Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression
Age is a major risk factor for the development of cancer. Senescent fibroblasts, which accumulate with age, secrete pro-tumorigenic factors collectively referred to as the senescence-associated secretory phenotype (SASP). Here we examined the molecular mechanisms that control SASP activation, focusi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605047/ https://ncbi.nlm.nih.gov/pubmed/22422937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3386 |
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