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Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression

Age is a major risk factor for the development of cancer. Senescent fibroblasts, which accumulate with age, secrete pro-tumorigenic factors collectively referred to as the senescence-associated secretory phenotype (SASP). Here we examined the molecular mechanisms that control SASP activation, focusi...

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Autori principali: Pazolli, Ermira, Alspach, Elise, Milczarek, Agnieszka, Prior, Julie, Piwnica-Worms, David, Stewart, Sheila A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605047/
https://ncbi.nlm.nih.gov/pubmed/22422937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3386
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