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The kinase activity of the Helicobacter pylori Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase is sensitive to distal mutations in its putative ammonia tunnel

The Helicobacter pylori (Hp) Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase (AdT) plays important roles in indirect aminoacylation and translational fidelity. AdT has two active sites, in two separate subunits. Kinetic studies have suggested that interdomain communication occurs between these subunits...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhao, Liangjun, Dewage, Sajeewa W., Bell, Michael J., Chang, Keng-Ming, Fatma, Shirin, Joshi, Nilesh, Silva, Gayathri, Cisneros, G. Andrés, Hendrickson, Tamara L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604897/
https://ncbi.nlm.nih.gov/pubmed/22229412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201143x
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