Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers

The phosphatidylinositol 3-kinase (PI3K) pathway is one of the critical signaling cascades playing important roles in the chemoresistance of human cancer cells, including ovarian cancer. In this study, we investigated the potential of targeting the PI3K p110β-isoform as a novel approach to overcome...

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Hlavní autoři: Jeong, Ju-yeon, Kim, Kyung-Sul, Moon, Ji-Sook, Song, Ji-ae, Choi, Sung-ho, Kim, Kwang-il, Kim, Tae-Heon, An, Hee-Jung
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2013
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604599/
https://ncbi.nlm.nih.gov/pubmed/23371322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-013-0807-9
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