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Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers

The phosphatidylinositol 3-kinase (PI3K) pathway is one of the critical signaling cascades playing important roles in the chemoresistance of human cancer cells, including ovarian cancer. In this study, we investigated the potential of targeting the PI3K p110β-isoform as a novel approach to overcome...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Jeong, Ju-yeon, Kim, Kyung-Sul, Moon, Ji-Sook, Song, Ji-ae, Choi, Sung-ho, Kim, Kwang-il, Kim, Tae-Heon, An, Hee-Jung
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer US 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604599/
https://ncbi.nlm.nih.gov/pubmed/23371322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-013-0807-9
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