A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles

Nanoparticles (NPs) have been shown to accumulate in organs, cross the blood–brain barrier and placenta, and have the potential to elicit developmental neurotoxicity (DNT). Here, we developed a human embryonic stem cell (hESC)-derived 3-dimensional (3-D) in vitro model that allows for testing of pot...

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Detalhes bibliográficos
Main Authors: Hoelting, Lisa, Scheinhardt, Benjamin, Bondarenko, Olesja, Schildknecht, Stefan, Kapitza, Marion, Tanavde, Vivek, Tan, Betty, Lee, Qian Yi, Mecking, Stefan, Leist, Marcel, Kadereit, Suzanne
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2012
Assuntos:
In Vitro Systems
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604581/
https://ncbi.nlm.nih.gov/pubmed/23203475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-012-0984-2
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